circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: hsa-miR-7
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ESCC cell (KYSE150, KYSE140, KYSE70, Eca9706, EC18, TE13), human esophageal epithelial cell line (HEEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF4, MMP2
Associated microRNA: hsa-miR-7
Biological function: promote the migration and invasion
Molecular mechanism: via hsa-miR-7/KLF4 and NF-kappaB signals
Survival: -
Supported No.:
 4
Description:

Our present study revealed that ciRS-7 can trigger the migration and invasion of ESCC cells via miR-7/KLF4 and NF-¦ĘB signals. Targeted inhibition of ciRS-7 might be a potential approach for ESCC treatment.
Other information
Title:

Circular RNA ciRS-7 triggers the migration and invasion of esophageal squamous cell carcinoma via miR-7/KLF4 and NF-kappaB signals.

Journal: Cancer Biol Ther
Published: 2018/9/13
PubMed ID: 30207835