circRNA basic information
circBase ID: hsa_circ_0001946
Name: rno_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: rno-miR-7
 
 
 
Disease basic information
DO ID:
 0050156
DO name: idiopathic pulmonary fibrosis
Disease details: silica-induced pulmonary fibrosis
Species: rat
Species details: rat
Sample type: tissue, cell line
Sample type details: human bronchial epithelial cells (HBE), human lung adenocarcinomic alveolar basal epithelial cells (A549), human fetal lung fibroblast cells (MRC-5), mouse fibroblast cells (NIH/3T3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TGFBR2
Associated microRNA: rno-miR-7
Biological function: -
Molecular mechanism: circRNA CDR1as stimulated by silica could sponge miR-7 to release TGFBR2, plays an important role during pulmonary fibrosis by promoting EMT process
Survival: -
Supported No.:
 1
Description:

CircRNA CDR1as stimulated by silica could sponge miR-7 to release TGFBR2, plays an important role during pulmonary fibrosis by promoting EMT process.
Other information
Title:

The CDR1as/miR-7/TGFBR2 Axis Modulates EMT in Silica-Induced Pulmonary Fibrosis.

Journal: Toxicol Sci
Published: 2018/9/12
PubMed ID: 30202956