circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: cir-ITCH, circ-ITCH
Host Gene: hsa-miR-22-3p
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: PTC cell lines (K1, IHH4, TPC1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: CBL, beta-catenin
Associated microRNA: hsa-miR-22-3p
Biological function: suppresses PTC cell proliferation and invasion and promotes apoptosis
Molecular mechanism: circ-ITCH sponges hsa-miR-22-3p to upregulate the expression of CBL, an E3 ligase of nuclear beta-catenin. Elevated levels of CBL suppress activation of the Wnt/beta-catenin pathway and consequently attenuates PTC progression
Survival: -
Supported No.:
 1
Description:

In summary, our study reveals a novel signaling pathway of circ-ITCH/miR-22-3p/CBL/beta-catenin involved in PTC development and progression.
Other information
Title:

CircRNA circ-ITCH suppresses papillary thyroid cancer progression through miR-22-3p/CBL/beta-catenin pathway.

Journal: Biochem Biophys Res Commun
Published: 2018/9/8
PubMed ID: 30190130