circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA_100290
Host Gene: hsa-miR-516b
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: human CRC cell lines (HCT116, SW480, HT29, SW620), normal colon epithelial cell line (NCM460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FZD4
Associated microRNA: hsa-miR-516b
Biological function: promote cell proliferation migration and invasion abilities and inhibit cell apoptosis
Molecular mechanism: circRNA_100290 was a competing endogenous RNA (ceRNA) of FZD4 by sponging hsa-miR-516b, leading to activation of Wnt/beta-catenin pathway
Survival: poor
Supported No.:
 1
Description:

CircRNA_100290 promotes colorectal cancer progression through miR-516b-induced downregulation of FZD4 expression and Wnt/beta-catenin signaling.
Other information
Title:

CircRNA_100290 promotes colorectal cancer progression through miR-516b-induced downregulation of FZD4 expression and Wnt/beta-catenin signaling.

Journal: Biochem Biophys Res Commun
Published: 2018/9/4
PubMed ID: 30173892