circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: cir-ITCH, circ-ITCH
Host Gene: hsa-miR-7, hsa-miR-20a, hsa-miR-214
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human CRC cell lines (HCT116, SW480)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-7, hsa-miR-20a, hsa-miR-214
Biological function: -
Molecular mechanism: inhibiting Wnt nad beta-Catenin pathway, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Cir-ITCH expression was typically down-regulated in CRC compared to the peritumoral tissue. This result, as well as several follow-up experi- ments, showed that cir-ITCH could increase the level of ITCH, which is involved in the inhibi- tion of the Wnt/beta-catenin pathway.
Other information
Title:

cir-ITCH plays an inhibitory role in colorectal cancer by regulating the Wnt/beta-catenin pathway.

Journal: PLoS One
Published: 2015/6/26
PubMed ID: 26110611